Approximately 40% of dementia cases are preventable or can be delayed.

“a lot of the the work and thought I've done in this arena is is not on my own you know I primarily have worked a lot with Dr Josh turkner who is a neurologist which I am not — and obviously has a lot of sort of front-facing experience in this and so a lot of these ideas as they come together you know we we wrote a paper about the demand model that's where you know some of this discussion comes from but it's very much a collaboration with with him and others so I won't pretend that I suddenly figured anything out by myself because I certainly didn't — nor can I say that I figured it out or else I'd be getting an invite from the king of Sweden — some time to go and let's go and meet him — but when we look at late ulcer Alzheimer's disease I think we've gotten to the point where there's such a broad number of environmental and lifestyle-based risk factors that seem to be critically important — that's really where I would focus my efforts and you can definitely say that even if the the brain is responding to neurological stresses or you know the absence of expected inputs with the accumulation of certain pathological Hallmarks there's still some Upstream process that's driving that and that's where I would want to focus and you know I I think our our best evidence so far is in factors around diet lifestyle and and you know peripheral peripheral Health you know cardiovascular health being a critical being an important one there was a Atlantic commission report in 2020 that looked at dementia broadly and tried to estimate what amount of dementia What proportion of dementia would be preventable and they estimated that 40 of dementia is preventable based on you know population attributable risk and a bunch of different risk factors”