Bryan Johnson
Bryan Johnson is the world's most measured human. Johnson sold his company, Braintree Venmo, to PayPal for $800m in 2013. Through his Project Blueprint, Johnson has achieved metabolic health equal to the top 1.5% of 18 year olds, inflammation 66% lower than the average 10 year old, and reduced his speed of aging by the equivalent of 31 years. Johnson freely shares his protocols and data publicly for everyone to use. Project Blueprint, is an endeavor to achieve humanity and earth scale cooperation starting within Self. Johnson is also the founder of Kernel, creator of the world’s first mainstream non-invasive neuroimaging system; and OS Fund, where he invested $100M in the predictable engineering of atoms, molecules, and organisms. He is an outdoor adventure enthusiast, pilot, and author of children’s books, Code 7 and The Proto Project.
Should I take creatine?
Yes, for almost everyone. 5g monohydrate daily, no loading phase needed.
Should I take rapamycin?
For healthy adults at standard weekly doses: Partially Supported. For those with kidney issues or active infection: not without a physician.
Rapamycin will extend human lifespan by 5+ years at standard weekly dosing.
Chronic low-dose rapamycin imposes an immune trade-off that outweighs the longevity hypothesis for most healthy adults.
Chronic rapamycin meaningfully increases infection risk in immune-naive healthy adults.
NAD+ precursors and senolytics can substitute for rapamycin's longevity effects in humans.
Rapamycin raises fasting glucose and worsens insulin sensitivity in a meaningful subset of users.
Post-meal glucose spikes in non-diabetics drive long-term cardiometabolic disease independently of HbA1c.
Paste the URL — video, podcast, article, or paper — and we'll extract every claim and grade it against the literature.
Audit a URL →Native comments, Twitter mentions, and Reddit threads about Bryan — surfaced together so the conversation isn't fragmented across platforms.
Bookmarking — the dossier-vs-overview split is the right call. Most of the time I want overview; sometimes I want receipts.
Would love a "what would change this verdict" RSS feed. Sign me up if it exists.