Evidence Score · 67 claims audited
Bryan Johnson
Blueprint founder · documents his anti-aging protocol.
Evidence Score
87
Strongest on
Sleep
Decisions · 2
where Bryan has taken a position
Stance
Skeptic
Should I take creatine?
Yes, for almost everyone. 5g monohydrate daily, no loading phase needed.
WELLSUPPORTED
Skeptic
Should I take rapamycin?
For healthy adults at standard weekly doses: Partially Supported. For those with kidney issues or active infection: not without a physician.
PARTIALLYSUPPORTED
Evidence Score by topic
3 topics · tap to see the claims
Claims · 12
distinct propositions Bryan has made
Topic
Bryan Johnson · Author · 1 creator · 3 mentions
Rapamycin will extend human lifespan by 5+ years at standard weekly dosing.
High riskRapamycinFrom Bryan Johnson's Blueprint Rapamycin Protocol
NOTSUPPORTED
Evidence Score19
David Sinclair · PhD · 2 creators · 5 mentions
Chronic low-dose rapamycin imposes an immune trade-off that outweighs the longevity hypothesis for most healthy adults.
High riskRapamycinFrom Sinclair on rapamycin alternatives
PARTIALLYSUPPORTED
Evidence Score61
David Sinclair · PhD · 3 creators · 5 mentions
Chronic rapamycin meaningfully increases infection risk in immune-naive healthy adults.
High riskRapamycinFrom Sinclair on rapamycin alternatives
LIMITEDRESEARCH
Evidence Score51
David Sinclair · PhD · 2 creators · 4 mentions
NAD+ precursors and senolytics can substitute for rapamycin's longevity effects in humans.
Low riskRapamycinFrom Sinclair on rapamycin alternatives
NOTSUPPORTED
Evidence Score26
Peter Attia · MD · 3 creators · 5 mentions
Rapamycin raises fasting glucose and worsens insulin sensitivity in a meaningful subset of users.
Med riskRapamycinFrom Peter Attia on Rapamycin (with Matt Kaeberlein)
PARTIALLYSUPPORTED
Evidence Score76
Peter Attia · MD · 3 creators · 11 mentions
Post-meal glucose spikes in non-diabetics drive long-term cardiometabolic disease independently of HbA1c.
Low riskCgm
LIMITEDRESEARCH
Evidence Score54
Content · 1
every piece by Bryan Whalespan has audited
DateTitleSupport
2026-04-22
Bryan Johnson's Blueprint Rapamycin Protocol
Post·protocol page + tweets
26%
Papers cited · 5
evidence base Bryan draws from
A-
International Society of Sports Nutrition position stand: safety and efficacy of creatine supplementation in exercise, sport, and medicine
Kreider et al. · 2017 · J. Int. Society of Sports Nutrition · Position statement
B+
Effects of creatine supplementation on cognitive function of healthy individuals: a systematic review of randomized controlled trials
Avgerinos et al. · 2018 · Experimental Gerontology · Systematic review
B+
Entrainment of the human circadian clock to the natural light-dark cycle
Wright et al. · 2013 · Current Biology · Prospective cohort
B+
Evening use of light-emitting eReaders negatively affects sleep, circadian timing, and next-morning alertness
Chang et al. · 2015 · PNAS · Randomized controlled trial
More from Bryan
Have a recent video from Bryan you want audited?
Paste the URL — video, podcast, article, or paper — and we'll extract every claim and grade it against the literature.
Audit a URL →Discussion
Native comments, Twitter mentions, and Reddit threads about Bryan — surfaced together so the conversation isn't fragmented across platforms.
M
Share your read of Bryan…
Posting publicly as you · linked to your social profiles
Sort by:
AV
A. Volkovreader
4hBookmarking — the dossier-vs-overview split is the right call. Most of the time I want overview; sometimes I want receipts.
NP
N. Park
2dWould love a "what would change this verdict" RSS feed. Sign me up if it exists.