We can't find evidence that holds up here. Proponents are reasoning from mechanism or analogy rather than direct human data, and the most credible skeptics raise objections we can't dismiss.
I think that this literature is wildly confounded by unhealthy user bias so let's go back to my labs and I will take it from the top you can see here my thyroid stuff this is really important guys your thyroid needs to work my TSH is 1.13 I would not want to see that above 1.5 in anyone my T4 is 1.17 these are both essentially exactly what they were in August of 2022.
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Bookmarking — the dossier-vs-overview split is the right call. Most of the time I want overview; sometimes I want receipts.
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the data connecting saturated fat with increased rates of Alzheimer's in those with apoe4 variants and their genetics are likely epidemiologic confounding that is unhealthy user bias there's no mechanistic way that saturated fat what worse than Alzheimer's disease
data connecting saturated fat with increased rates of Alzheimer's in those with apoe4 variants and their genetics are likely epidemiologic confounding that is unhealthy user bias
the data linking saturated fat with Alzheimer's I think is really shoddy medical detective work and it's just confounded by unhealthy user bias those eating more saturated fat are probably eating a lot of junk food along with that saturated fat because it's saturated fat from McDonald's and often in these studies hydrogenated trans fat gets lumped in with saturated fat