Does APOE4 affect longevity?

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Paul Saladino9m · 2022-12-22

Claims Made

19

Claims Supported

15

Support Rate

79%

Support rate

15 of 19 claims supported

15 supported4 partial / not

Claims from this content

17

Well SupportedThe APOE4 genotype is the major genetic risk factor for Alzheimer's disease, with risk increasing in a dose-dependent manner.Well SupportedAnimal foods rich in saturated fats offer benefits including increasing HDL, hormones, and testosterone, and serving as precursors for hormones.Well SupportedPaul Saladino remains insulin sensitive despite significant carbohydrate consumption due to his blood work foundation and not being obese or diabetic.Well SupportedThe APOE4 allele emerged relatively recently in human evolution, suggesting that for the majority of human history, individuals possessed the APOE2 or APOE3 alleles.Well Supported

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A. Volkovreader

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Bookmarking — the dossier-vs-overview split is the right call. Most of the time I want overview; sometimes I want receipts.

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Individuals with the APOE4 genotype had a lower risk of developing dementia, particularly Alzheimer's, in a metabolically healthy Nigerian population.

Well SupportedHaving two copies of the APOE4 gene variant likely means a person will develop advanced Alzheimer's disease.

Well SupportedMaintaining insulin sensitivity is critical for individuals, and checking fasting insulin levels is important for assessing metabolic health.

Well SupportedFasting insulin levels are often very high in patients with early hyperinsulinemia.

Well SupportedIn the Semai population, APOE4 is associated with improved cognitive function in metabolically healthy individuals facing high parasite and pathogen load.

Well SupportedLifestyle factors like diet, environment, and insulin resistance status can influence Alzheimer's risk in APOE44 carriers.

Well SupportedTrans fatty acids formed from heating and hydrogenation of vegetable oils inhibit prostacyclin and promote thromboxane, increasing the likelihood of blood clotting.

Not SupportedThe literature linking saturated fat with Alzheimer's is confounded by unhealthy user bias, where high saturated fat intake correlates with junk food and trans fat consumption.

Not SupportedIndividuals with APOE4 do not need to avoid saturated fat due to a lack of mechanistic basis for saturated fat worsening Alzheimer's disease.

Partially SupportedInsulin sensitivity is a crucial factor in how an individual's body handles their genetics.

Partially SupportedSeed oils, not carbohydrates, honey, maple syrup, or fruit, are believed to cause insulin resistance by damaging mitochondria and cardiolipin.

Partially SupportedOdd-chain fatty acids in animal foods are likely beneficial for cognitive decline.

Partially SupportedHigh LDL cholesterol is often associated with insulin resistance in Western populations.