Andrew Huberman· PhD
the next most common is the 34 which is about 25% of the population
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The evidence is convergent. Multiple independent sources reach the same conclusion, the underlying mechanism is well-characterized, and even the field's most cautious voices treat it as worth doing.
the next most common is the 34 which is about 25% of the population
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um we're we're trying to decide so we do genetic screening for certain things like apoe is a gene we want to know in everybody um for its role in neurod degenerative disease correct uh specifically in Alzheimer's disease
33 is now the most common three is the most common so double three is 50 5 is% of the population
and if you have two copies is maybe like five times that so 10 to 20% something like that and that so that's why people are getting you know pretty worked up about it and so if you're gonna get Alzheimer's disease maybe by the time you're 70 or 80 years old if you have to a pony for copies and you live in the Western world you probably probably about a 90 percent chance of getting out Simon's disease
it is true that if you look across the population those with two copies of apoe4 in their genetics do have an increased risk of Alzheimer's
I would say 30 based on the systems I've seen 30 to 55 of people with apoe44 develop Alzheimer's that's a big number but the flip side is that 70 to 45 percent of people with 8.44 don't get Alzheimer's
I would say 30 based on the statistics I've seen 30 to 55 of people with apoe44 develop Alzheimer's that's a big number but the flip side is that 70 to 45 percent of people with apoe44 don't get Alzheimer's
it makes me think of the apoE genotype which is linked to Alzheimer's disease and there we see that there is a difference about 25% of the population carries at least one copy of that gene and they represent about two-thirds of the cases of Alzheimer's disease it's not a deterministic gene but it does increase risk
you've got about a 10 risk reduction relative to the 3-3 but the 3-3 is clearly not at risk
you have two copies of APO E4 a set from your mom and a set from your dad and what does that mean exactly that means you have an increased risk of Alzheimer's disease how much oil probably somewhere between 8 and 10 times higher than that of someone in the general population
the APO E4 as you just pointed out the apoe4 form which is present about 25 of people so it's quite common and even in the homozygous form you know certainly plenty of people out there who have both two copies is in a dose-dependent way the major genetic risk factor for Alzheimer's disease no question about it
about two-thirds have at least one copy of the APO E4 Gene now to put that in context about 25 of the general population has at least one copy of the apoe4 gene so 25 of the population has at least a copy of one copy of E4 and by the way most of them are just one copy two copies is pretty rare that's about two percent of the population but that 25 of the population makes up two-thirds of all cases of Alzheimer's disease
it's important to note it's not deterministic no it's not determination and in fact it's far less penetrant than FH is yes there are lots of people walking around with APO E4 that are not getting Alzheimer's disease
65 percent have an apple E4 molecule on board they're either e44 or E34 or e2e4 so they have an E4
if you look at late onset sporadic Alzheimer which is the vast majority of Alzheimer patients 65 percent have an apple E4 molecule on board they're either e44 or E34 or e2e4
if you have E4 E4 your risk for Alzheimer is 16 times higher than when you have E3 E3
People who have one copy typically a three and a four are at about a two times risk
People who have one copy typically a three and a four are at about a two times risk
you know 25% of the population are hetererozygous for APOE4 and and they're you know their risk is twofold higher
The APOE4 genotype, found in roughly 25% of the population, boosts the risk of Alzheimer's disease by 2 to 11 times, with the risk increasing depending on the number of copies present.
If you look at Alzheimer's, people with Alzheimer's, between 65 and 80% of all people who have Alzheimer's have one allele of ApoE4.
Between 65% and 80% of all cases of Alzheimer's disease at least, you know... At least one has a 4.
The majority of people with Alzheimer's are not 3/4 or 4/4, they're still 3/3. The difference is this...because remember, the 3/3 is the majority of the population. I mean the 3/4 is actually pretty big, it's about 20%. But the 3/3 is the largest one, so having a 3/3 doesn't protect you from Alzheimer's and having a 3/4 doesn't guarantee you're going to get it. And, by the way even a 4/4 doesn't guarantee you're going to get it.
On the other hand, if you have a single copy of ApoE4 your lifetime risk is about 30% or so. If you have two copies, if you're homozygous, your lifetime risk is over 50%, and in some studies as high as 90%.