Paul Saladino· MD
it is true that if you look across the population those with two copies of apoe4 and their genetics do have an increased risk of Alzheimer's
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The evidence is convergent. Multiple independent sources reach the same conclusion, the underlying mechanism is well-characterized, and even the field's most cautious voices treat it as worth doing.
it is true that if you look across the population those with two copies of apoe4 and their genetics do have an increased risk of Alzheimer's
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now the difference between apo e4 having one variant or two i'll explain that in a second means if you get the e4 it doesn't mean you're going to get alzheimer's it just increases your risk
even though you have two copies of the apoe4 gene which is a very rare combination you know 20 to 25% of the population has at least one copy of the E4 Gene and even though that doesn't increase their risk as much as the increase that you experience it still does in fact even though it's only 20 to 25% of the population that has that Gene that group of people makes up about two-thirds of cases of Alzheimer's disease
if you have two copies you are destined to have it.
but but I you know I don't think anyone would consider that sort of destiny. >> Yeah, your genes are not your destin. I don't want to make that >> sort of assumption but it puts you at greater risk for sure.