The evidence is convergent. Multiple independent sources reach the same conclusion, the underlying mechanism is well-characterized, and even the field's most cautious voices treat it as worth doing.
the E4 isopor is the OG isopor that's the one that we have historically had as as far back as we can go — the E3 isopor I think showed up God I think 50,000 years ago and the E2 isopor showed up very recently about 10,000 years ago
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Native comments, Twitter mentions, and Reddit threads about this claim — surfaced together so the conversation isn't fragmented across platforms.
Bookmarking — the dossier-vs-overview split is the right call. Most of the time I want overview; sometimes I want receipts.
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so like you're saying I guess what I'm saying here is a pro e for a rose eight million years ago from what I learned uh-huh and that was what we had through the majority of our evolution as humans yeah so for the majority of our time as humans which I would argue was mostly carnivorous based upon stable nitrogen isotope studies and whatever we had a bowi for and April III only showed up 220,000 years ago a bowi to only showed up eighty thousand years ago
The APOE4 allele is the most primordial allele of a Polly it's the most recent it's well they believe for yes most recent well it's that one's been around for eight million years and then April III happened 220,000 years ago yeah so like you're saying I guess what I'm saying here is a pro e for a rose eight million years ago from what I learned uh-huh and that was what we had through the majority of our evolution as humans yeah so for the majority of our time as humans which I would argue was mostly carnivorous based upon stable nitrogen isotope studies and whatever we had a bowi for and
and the other thing that's fascinating to me about a tweet for is that's our genetic history maybe we three didn't show up until like two one hundred thousand years ago so for the majority of human evolution we all had a belief or
apoe4 is an isoform a polymorphism in the apoe4 gene that has been present throughout the entirety of human evolution
apoe3 appears to have arisen i believe 200 000 years ago april e2 about 80 000 years ago those numbers could be a little bit give or take
it's important to know that apoe4 is the ancestral genotype of apoe apoe is an apollo of a protein present in our bodies and apoe4 is what all of our primate ancestors had and what all of humans and pre-hominids had for millions of years
historically apoe4 was the variant that prehominids and humans had for hundreds of thousands of years it appears that apoe3 only arose 200 000 years ago and apoe two about eighty thousand years ago this means for the majority of our Evolution as Homo habilis Homo erectus pre-hominids we were all apoe44 and Homo sapiens appears to have arrived on the scene about 350 400 000 years ago so perhaps for half or close to half of our existence as Homo sapiens everyone your mom your grandmother your brother your sister your dad they were all you were all apoe44 this genetic variant clearly had some benefit for us