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What the heck causes INFLAMMATION and how to correct it with Dr. Will Cole.

PS

Paul Saladino1h 21m · 2019-12-24

Support Rate

59%

88 of 149 claims supported

Support rate

88 of 149 claims supported

88 supported61 partial / not

Claims from this content

115

Well SupportedRegenerative agriculture practices improve soil organic matter, leading to more nutritious food.Well SupportedHumans likely consumed meat with saturated fat throughout evolution, and meat consumption may have driven brain growth.Well SupportedThe APOE4 allele emerged relatively recently in human evolution, suggesting that for the majority of human history, individuals possessed the APOE2 or APOE3 alleles.Well SupportedHigh-sensitivity C-reactive protein (hs-CRP) below 3 mg/dL is considered low, and specific testing is required to measure levels below 3 mg/dL.Well SupportedInsulin resistance is a major confounding factor in understanding health outcomes, particularly for individuals with the APOE4 genotype.

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A. Volkovreader

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Bookmarking — the dossier-vs-overview split is the right call. Most of the time I want overview; sometimes I want receipts.

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Would love a "what would change this verdict" RSS feed. Sign me up if it exists.

Well SupportedA fasting insulin level above 4 or 5 micro IU/mL warrants consideration of insulin resistance.

Not SupportedPaul Saladino experiences eczema, autoimmunity, and skin issues when consuming dairy, regardless of milk type.

Well SupportedConsuming animal intestines may improve gut health by providing cofactors, growth factors, and nutrients.

Well SupportedGrass-fed desiccated animal organ supplements can preserve nutritional content and improve health.

Well SupportedSome plant foods can trigger immunologic reactions and cause inflammation, particularly in individuals with autoimmune tendencies.

Well SupportedInflammation in the brain has been linked to worse outcomes in suicide, depression, and anxiety.

Partially SupportedNightshade vegetables like eggplant, goji berries, and peppers can negatively affect eczema and immune systems for some individuals.

Partially SupportedSaturated fat can be problematic for individuals with underlying gut inflammation, potentially contributing to issues like endotoxemia.

Partially SupportedThe claim that saturated fat in ketogenic or carnivore diets creates lipid rafts that increase postprandial endotoxemia is a point of contention.

Partially SupportedPaul Saladino's book, 'The Carnivore Code,' is 300 pages, contains 650 references, and was available in print and as an e-book on February 25th.

Partially SupportedThe A1 variant of casein, found in most cows' milk in the United States, has been associated with increased autoimmune disease in some studies.

Well SupportedIndividuals benefiting from a strict elimination diet like carnivore should consider gradually reintroducing plant phytochemicals and fiber for a more balanced diet.

Partially SupportedLipid peroxides and 8-hydroxy-2-deoxyguanosine indicate oxidative damage.

Partially SupportedNo single test result should be interpreted in isolation; context from prior tests and trends is crucial for accurate assessment.

Partially SupportedF2-isoprostane to creatinine ratio is a marker of oxidative stress.

Partially SupportedA ketogenic diet can improve cognitive function and insulin resistance in individuals with APOE4 and type 2 diabetes.

Not SupportedProcessed vegetable oils like canola oil should be avoided.

Partially SupportedPEG 400 testing is considered the best available method for assessing leaky gut.

Well SupportedChronic, low-grade inflammation is problematic and linked to many health issues.

Not SupportedStudies on food lectins and red blood cells in test tubes do not demonstrate a clear physiological basis or correlation in the human body for the blood type diet.

Partially SupportedAdjusting the ketogenic diet may be necessary if it is not yielding desired results, rather than abandoning it entirely.

Well SupportedInflammation is at the root of almost all health problems.

Partially SupportedA well-formulated, nutrient-dense carnivore diet can be used as an elimination diet to manage severe food reactions and inflammation, allowing the gut to repair.

Partially SupportedInflammation is a common factor in most modern health problems, including autoimmune conditions, digestive problems, metabolic issues, diabetes, heart disease, and cancer.

Partially SupportedHomocysteine and hs-CRP can be measured through standard lab tests.

Partially SupportedSome individuals can have adverse reactions to eggs, and the source of the eggs may influence reactivity.

Partially SupportedA widespread issue of metabolic dysfunction (87.8% of US individuals) may influence study outcomes.

Partially SupportedIndividuals without insulin resistance may not experience the same negative health effects from certain dietary factors as those with insulin resistance.

Partially SupportedGenetic factors like APOE4 and MTHFR, and the endocannabinoid system, are considered in assessing inflammation.

Partially SupportedDr. Will Cole's books, 'Ketotarian' and 'The Inflammation Spectrum,' are recommended resources.

Partially SupportedMany people settle for suboptimal health due to aging or stress, when they could optimize their health and overcome these issues.

Partially SupportedRaising awareness of the inflammation spectrum is important because people need to know what they are facing to address it.

Partially SupportedA clean, well-formulated, and nutrient-dense carnivore diet can be used as an ultimate elimination diet.

Partially SupportedChildren playing in dirt and in the natural world can lead to diverse gut microbiota.

Not SupportedDairy, including A2 dairy and raw goat's milk, may negatively impact weight loss, skin conditions like eczema and psoriasis, and overall health.

Not SupportedThe benefits of the blood type diet are likely due to adopting a whole foods diet and eliminating processed foods, not specific blood type recommendations.

Partially SupportedThe interplay of genetics, epigenetics, insulin resistance, and gut health influences health outcomes.

Partially SupportedThe ApoE allele, in combination with insulin resistance and gut issues, can be a problematic factor for health.

Partially SupportedIndividuals are more than their genetics, and a specific gene allele does not guarantee a particular health problem.

Partially SupportedEvery food either feeds inflammation or fights it, influencing biochemistry and the microbiome.

Partially SupportedRed meat can be a healthy part of a balanced diet.

Partially SupportedOxidized vegetable oils like corn oil can damage the gut and induce leaky gut.

Partially SupportedRed meat is a source of many beneficial nutrients.

Partially SupportedAssessing the gut's mucosal lining and testing for lipopolysaccharide antibodies and zonulin antibodies can evaluate intestinal barrier function.

Partially SupportedMany conditions attributed to aging, new motherhood, or weight issues have measurable underlying causes that can be corrected.

Partially SupportedBeta-hydroxybutyrate can act as an epigenetic modulator and lower inflammation levels.

Partially SupportedHigh levels of gut immune markers such as haptoglobin and lactoferrin can indicate that gut inflammation is contributing to systemic inflammation.

Partially SupportedFunctional medicine practitioners assess gut-centric inflammation, including markers like lipopolysaccharides, dysbiosis, and intestinal permeability.

Partially SupportedSymptoms experienced daily may be signs of inflammation and should not be accepted as normal.

Partially SupportedTaking actions to reduce and modulate inflammation allows the body to repair and recover.

Partially SupportedInflammation in one area of the body can spread to other areas, a phenomenon called polyinflammation.

Partially SupportedInflammation is essential for optimal immune function, cellular function, and fighting viruses and bacteria when in check.

Partially SupportedAutoimmunity is always inflammatory, but inflammation does not necessarily imply autoimmunity.

Partially SupportedIndividuals with the HFE H63D polymorphism may absorb iron more avidly, potentially leading to elevated ferritin, especially on a carnivore diet, and may benefit from donating blood.

Partially SupportedFerritin levels around 270 may indicate excess iron, especially if hs-CRP is normal.

Partially SupportedBalanced inflammation is essential for immune function, fighting pathogens, and cellular function.

Partially SupportedInflammation is a product of the immune system and is not inherently bad, but should be kept in check and calm down when not needed.

Partially SupportedThe book 'The Carnivore Code' can be pre-ordered via thecarnivorecodebook.com or carnivoremd.com.

Partially SupportedHigh saturated fat intake can appear benign in individuals with excellent inflammation markers and NMR panels.

Partially SupportedSaturated fat is a necessary component of every human cell membrane and is not inherently dangerous on its own.

Partially SupportedConsuming large amounts of meat and dairy, especially from conventional sources, may lead to long-term problems for some individuals.

Partially SupportedThe inflammation spectrum ranges from mild symptoms like fatigue and anxiety to severe conditions like autoimmune diseases.

Partially SupportedThe ketogenic diet, when consumed in a 'cleaner' way, can help individuals achieve ketosis and metabolic flexibility, especially those who primarily rely on carbohydrates for fuel.

Partially SupportedGhee is a casein-free option for individuals on a ketogenic diet who have issues with dairy.

Partially SupportedA carnivore diet with organ meats and fish can down-regulate inflammation and allow gut repair in individuals with severe food reactions.

Partially SupportedCellular inflammation impacts cell membranes and mitochondria, leading to systemic cascades linked to chronic inflammatory health problems.

Partially SupportedGut testing like GI-MAP or calprotectin can identify gut issues, though some with problems may not show elevated calprotectin.

Partially SupportedMany women who avoid red meat may be misdirecting their focus from health priorities.

Partially SupportedCoconut oil may be more problematic than red meat regarding saturated fat content and its effects.

Partially SupportedMany women are told that red meat or meat in general is unhealthy or fattening.

Partially SupportedDr. Will Cole includes a significant amount of animal products in his diet.

Partially SupportedReintroducing certain plant foods after an elimination diet can cause systemic inflammatory symptoms, including depression, in some individuals.

Partially SupportedInflammation can manifest across different organ systems, leading to symptoms such as anxiety, depression, irritability, GI distress, acne, rheumatoid arthritis, gut problems, and rashes.

Partially SupportedContext is crucial when considering lipids, ApoE, and FTO gene polymorphisms, and their impact on health.

Partially SupportedMany health issues have measurable causes that can be improved, supported, healed, or reversed.

Partially SupportedFood sensitivities or microbiome imbalances can be recalibrated over time with appropriate infrastructure and enzymatic function.

Partially SupportedFor individuals with underlying gut inflammation, a low-fat approach may be beneficial until gut health is improved.

Partially SupportedSaturated fat did not induce leaky gut in a mouse model of alcoholic liver disease, while unsaturated fat did.

Not SupportedConventional medical doctors often do not run comprehensive lab tests to identify underlying causes of how people feel, leading to simple medication prescriptions instead of addressing root issues.

Partially SupportedThe brain relies on astrocytes for cholesterol transport, which may be impaired by insulin resistance and the APOE4 allele.

Partially SupportedThe cytokine model of depression, anxiety, schizophrenia, and bipolar disorder was not taught in psychiatry residencies at the University of Washington.

Partially SupportedThe Keto-terian diet offers a cleaner way to utilize carbohydrates for fuel, helping individuals gain metabolic flexibility and move away from primary reliance on sugar.

Partially SupportedCasein peptides in dairy can activate opiate pathways, potentially negatively affecting satiety and contributing to weight gain.

Not SupportedAnxiety and depression are not solely genetic and are correctable.

Partially SupportedA homozygous MTHFR C677T polymorphism does not necessarily lead to elevated homocysteine or associated health issues.

Not SupportedIndividuals with APOE4 polymorphisms do not necessarily need to avoid saturated fat.

Not SupportedLentils can trigger GERD, reflux, and eczema in individuals with blood type B.

Partially SupportedThe ketogenic diet can be a powerful tool for improving health outcomes, particularly for patients with autoimmune issues, digestive problems, neurological symptoms, and inflammatory conditions.

Partially SupportedAvoiding plant foods for extended periods can lead to the development of food reactivities due to a recalibrated microbiome.

Partially SupportedAncestral Supplements released new supplements including tallow in pill form.

Partially SupportedOrthorexia, characterized by stress and anxiety around eating whole or 'real' foods, can be a concern for individuals on restrictive diets like carnivore, ketogenic, or vegan diets.

Partially SupportedThe 'Keto-terian' diet is a mostly plant-centric ketogenic diet that includes grass-fed beef and pescetarian options.

Partially SupportedThe microbiome's ability to digest plant fibers can be restored through gradual reintroduction of cooked, pureed, lower FODMAP foods in soups and stews.

Partially SupportedGrains, added sugar, dairy, and high omega-6 oils are core food groups that commonly drive inflammation.

Partially SupportedCytokines impact mental health, brain function, and are connected to anxiety, depression, fatigue, and neuroinflammatory autoimmune problems.

Partially SupportedThe APOE4 allele appears to be protective against cognitive decline and inflammation in some indigenous populations.

Partially SupportedHomocysteine levels above 7 µmol/L are associated with neurotoxicity and neuroinflammation, and can increase blood-brain barrier permeability.

Partially SupportedFerritin can be misleading as an indicator of iron stores if inflammation is present, and other metrics like transferrin saturation should be considered.

Partially SupportedA ketogenic diet improved metabolic markers and cognitive function in an individual with insulin resistance and an ApoE4 allele.

Partially SupportedCoconut oil may be more problematic than red meat for individuals with certain genetic predispositions and insulin resistance.

Not SupportedThe idea that one cannot eat red meat due to ApoE4 allele status is a misinterpretation, as human ancestors consumed red meat before ApoE variations emerged.

Not SupportedFear-mongering around red meat and FTO gene polymorphisms is unwarranted, and individuals can choose nutrient-dense foods from various sources.

Not SupportedJoint pain, skin rashes, insomnia, constipation, diarrhea, anxiety, and depression can be signs of inflammation or autoimmune issues, not necessarily aging or genetics.

Partially SupportedSome individuals experience problems with traditional ketogenic diets, necessitating alternative tools like those in 'keto terian'.

Partially SupportedDairy sensitivities and casein reactivities can cause digestive problems, weight gain, and prevent full benefits of a ketogenic diet after the initial honeymoon period.

Partially SupportedHigh intake of saturated fat can raise inflammation and shift lipid profiles to pattern B in individuals with specific apoE gene alleles or significant intestinal permeability.

Partially SupportedA high-fat, low-carb diet may not be optimal for long-term health.

Partially SupportedA 'dirty keto' diet uses significant amounts of nut flours, sugar alcohols, and processed keto foods.

Not SupportedElevated ferritin levels should be avoided and can spike during inflammation.

Partially SupportedUbiquity of a condition does not equate to normalcy, and people should not settle for a poor quality of life due to common ailments.