The evidence is convergent. Multiple independent sources reach the same conclusion, the underlying mechanism is well-characterized, and even the field's most cautious voices treat it as worth doing.
it appears is that in people with insulin resistance they're they're uniquely susceptible to kind of a breakdown of their apoe4 movement of that cholesterol to the neurons and so my my hypothesis is that it's not a belief for that's bad that's that a belief or and the setting of insulin resistance is really bad and that that we haven't really been insulin resistant throughout our evolution
Every Sunday: the week’s new conflicts and verdict changes — and nothing else.
Native comments, Twitter mentions, and Reddit threads about this claim — surfaced together so the conversation isn't fragmented across platforms.
Bookmarking — the dossier-vs-overview split is the right call. Most of the time I want overview; sometimes I want receipts.
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what if one looks like it's happening is that a belief or is uniquely badly suited for our current environment of insulin resistance
there is a connection between insulin resistance and increased incidence of dementia in those with apoe4
I see insulin resistance as this hugely important context you and I have spoken about this on a previous podcast two years ago like swimming in dirty water what is the context of the people that we are looking at in these populations and for me insulin resistance is the main pollutant in that water
in terms of you know with epidemiological observational evidence I think you could say the former — particularly because in the studies that we have available large cohort studies — in the US or in different countries in Europe it certainly seems like apple E4 is a significant risk factor for long-term cognitive decline age-related dementia
because as you probably may know apoe4 by itself creates a system with aging that makes an individual insulin resistant so in one regards apoe4 could be a factor for why a certain person may get type 2 diabetes