AMA: Glyphosate, Sunning your balls, and APOE4

PS

Paul Saladino1h 1m · 2022-08-09

Claims Made

147

Claims Supported

114

Support Rate

78%

Support rate

114 of 147 claims supported

114 supported33 partial / not

Claims from this content

122

Well SupportedA fasting insulin level below 5 micro IU/mL is considered healthy.Well SupportedA recommended intake for organ meats is a few ounces per week, such as half an ounce to a few ounces of liver and a few ounces of heart per week.Well SupportedFor men, a protein intake of approximately 1 gram per pound of body weight per day is recommended, while for women, it's about 0.9 grams per pound of body weight.Well SupportedAn animal-based diet consisting of meat, organs, fruit, honey, and raw dairy may help with gut issues or autoimmune conditions.Well Supported

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A. Volkovreader

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Bookmarking — the dossier-vs-overview split is the right call. Most of the time I want overview; sometimes I want receipts.

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Would love a "what would change this verdict" RSS feed. Sign me up if it exists.

Cholesterol gallstones are typically formed due to an imbalance in cholesterol and phosphatidylcholine in bile, often caused by choline deficiency.

Well SupportedDiversifying organ consumption beyond muscle meat to include organs like liver, heart, testicles, spleen, or thymus leads to improved nutritional status.

Well SupportedSun exposure, particularly UVB light, is associated with positive increases in the gonadal axis and sexual behavior, potentially enhancing male testosterone levels.

Well SupportedInsulin-resistant individuals increasing meat intake should monitor uric acid and prioritize improving insulin sensitivity by eliminating processed sugar and seed oils.

Well SupportedThe speaker's fasting insulin is less than 3 micro IU/mL and C-peptide is less than 0.43, indicating no evidence of insulin resistance, despite daily honey consumption.

Well SupportedA baseline intake of at least 150 grams of carbohydrates per day is recommended, with active individuals potentially benefiting from 300 grams daily.

Well SupportedAn iron comprehensive panel should include serum iron, TIBC, ferritin, and percentage of transferrin saturation.

Well SupportedFish contains significantly higher preformed TMAO (40x more) than historically associated with cardiovascular disease.

Well SupportedIndividuals with the APOE4 genotype had a lower risk of developing dementia, particularly Alzheimer's, in a metabolically healthy Nigerian population.

Well SupportedA free animal-based macronutrient calculator is available on carnivoremd.com to help construct an animal-based diet.

Well SupportedCarbohydrate intake should be adjusted based on activity level, and most people benefit from some carbohydrates, though bio-individuality exists.

Well SupportedSunlight exposure stimulates the production of beta-endorphins, which are important for immune system health and wound healing.

Well SupportedInsulin resistance is a major confounding factor in understanding health outcomes, particularly for individuals with the APOE4 genotype.

Well SupportedAn animal-based diet aligns with ancestral principles and evolutionary biology for optimal health.

Well SupportedConsuming raw or undercooked liver from well-raised animals is safe, as freezing kills parasites and visual inspection can identify infectious agents.

Well SupportedBuying organic fruit and seeking honey from regions not near agriculture can help limit glyphosate exposure.

Well SupportedBrain insulin resistance, associated with Alzheimer's disease, is linked to IGF-1 resistance, IRS-1 downregulation, and cognitive decline.

Well SupportedLow-dose glyphosate exposure may contribute to non-alcoholic fatty liver disease.

Well SupportedThe animal-based 30 is a 30-day challenge to help individuals start an animal-based diet.

Well SupportedInsulin-sensitive individuals should know their fasting insulin to confirm sensitivity.

Well SupportedSun exposure, specifically to narrow-band UVB, can positively modulate the human intestinal microbiome.

Well SupportedA thyroid panel including T3, T4, TSH, free T3, and antibodies provides a good sense of thyroid health and is not prohibitively expensive.

Partially SupportedAndrosterone is a real androgen with approximately 1/7th the energetic activity of testosterone and may function as a pheromone.

Well SupportedHormone testing should include estrogen, progesterone, testosterone, DHEA, the androgen pathway, and estrogen metabolites, with attention to timing.

Partially SupportedThere is a lack of evidence showing tanning beds are uniquely damaging compared to the sun when intensity is controlled, time is limited, and burning is avoided.

Partially SupportedAPOE4 is the ancestral genotype of apolipoprotein E, present in all primate ancestors.

Partially SupportedPaul Saladino's uric acid levels are often below 4, even when consuming large amounts of meat, organs, fruit, and fructose.

Partially SupportedTanning beds that mimic the sun, with a UVA/UVB ratio like 95% UVA and 5% UVB, are a viable option for Vitamin D production when sun exposure is limited.

Not SupportedHoney consumption is not recommended unless accessed from pristine sources at least 20 miles from glyphosate-treated farms.

Partially SupportedPurine metabolism may be disordered in insulin resistance, contributing to elevated uric acid.

Partially SupportedProblems with APOE4 and saturated fat from animals would have been disadvantageous throughout human existence.

Partially SupportedGlyphosate may disrupt the gut microbiome by inhibiting the shikimate pathway, which is involved in folate production in plants.

Partially SupportedGlyphosate is persistent and ubiquitous, and precautions should be taken to limit exposure.

Partially SupportedGlyphosate can be found in various consumer products including food, diapers, medical gauze, feminine hygiene products, and clothing.

Partially SupportedA study found glyphosate in 62% of conventional honeys and 45% of organic honeys.

Partially SupportedKalima salt shows no microplastics under a microscope.

Partially SupportedGallbladder and bile contain nutrients that support the biliary tract, including choline, which are often absent in modern diets.

Partially SupportedCholine is important for converting to glycine, but excessive conversion should be avoided.

Partially SupportedAnimal-based diets and living in an ancestrally/evolutionarily consistent manner as humans can lead to people feeling better.

Partially SupportedIn indigenous populations living closer to a hunter-gatherer lifestyle, APOE4 does not appear to be harmful.

Partially SupportedA comprehensive metabolic panel should include electrolytes.

Partially SupportedSome German beers and pantyliners from an organic feminine hygiene company have been found to contain traces of glyphosate.

Partially SupportedMetabolic dysfunction, particularly insulin resistance, is strongly associated with hyperuricemia and gout.

Partially SupportedInquire about cooking methods and oils when eating out, as steakhouses often grill steaks.

Well SupportedPhosphatidylcholine is a beneficial supplement, but obtaining choline from food sources is preferred.

Partially SupportedThe speaker intentionally opts for organic cotton sheets and wool shirts due to concerns about glyphosate absorption through skin from conventional cotton.

Partially SupportedLaboratory tests have demonstrated that glyphosate can be absorbed through the gastrointestinal tract, inhalation, and dermal contact in humans and mammals.

Partially SupportedGlyphosate is transformed into AMPA, its main metabolite, which retains toxic characteristics and is even more persistent, with a half-life of 76 to 240 days.

Partially SupportedEliminating processed sugars and seed oils while focusing on beef and fruit will lead to improved insulin sensitivity.

Partially SupportedFood should be considered the first therapy or intervention for humans across all medical specialties.

Not SupportedGlyphosate is not benign for humans, and its safety is questionable based on recent studies.

Not SupportedCheat days often sabotage dietary adherence for most people.

Not SupportedThere are concerns about the long-term use of SSRI medications regarding neurotransmitters in the brain.

Partially SupportedTanning beds do not increase cancer risk more than sunlight exposure, and skin cancer predisposition may be linked to excess seed oil consumption.

Partially SupportedA ketogenic diet improved dementia symptoms, type 2 diabetes, and metabolic syndrome markers in a heterozygous APOE4 carrier.

Partially SupportedTanning beds are more intense than the sun and require gradual exposure and avoiding sunburn.

Partially SupportedConsuming beef organs can provide refreshment and energy when feeling sluggish.

Partially SupportedA ketogenic diet has strong potential to restore systemic insulin sensitivity and metabolic flexibility in diabetic individuals.

Partially SupportedConsuming a couple of tablespoons of honey can lead to satiety for several hours.

Partially SupportedIncreased cholesterol and LDL levels are associated with increased Alzheimer's risk in individuals without the APOE4 allele, but not in those with APOE4.

Partially SupportedGlyphosate was classified as a category C substance (limited evidence of carcinogenicity) in 1985 and a category E (no carcinogenic potential) in 1991 by the EPA.

Partially SupportedAn animal-based diet with 80% animal products and 20% other foods can be effective for health.

Well SupportedReverse osmosis filtration removes essential minerals like calcium, magnesium, and potassium from water.

Not SupportedEpidemiological associations between saturated fat and APOE4 are misleading because they do not account for the confounding factor of insulin resistance.

Partially SupportedAPOE4 appears to have been protective against parasitic infections.

Well SupportedAn advanced blood panel should include measurements for hematocrit, hemoglobin, MCH, MCHC, MCV, MPV, platelet count, RBC count, RDW, white blood cell count differentials (basophils, lymphocytes, monocytes, eosinophils, neutrophils), advanced lipids (total cholesterol, LDL, HDL, triglycerides, HDL large, LDL medium, LDL particle number, LDL pattern, LDL peak size, LDL small lipoprotein fractionation, non-HDL cholesterol), liver enzymes (ALT, AST), albumin, ALP, BUN, BUN/creatinine ratio, calcium, CO2, chloride, creatinine, eGFR, globulin, glucose, potassium, sodium, total bilirubin, total protein, SHBG, free and total testosterone, Apo B, cortisol, FSH, estradiol (male), ferritin, HbA1c, hs-CRP, homocysteine, insulin, Lp(a), LH, magnesium, TSH, uric acid, Vitamin D, Zinc, B12, folate, iron, iron % saturation, TIBC, omega-3 (EPA+DPA+DHA, total), omega-6 (arachidonic acid, linoleic acid, total), arachidonic acid/EPA ratio, omega-6/omega-3 ratio, IGF-1, ABO group and Rh factor, amylase, DHEA-Sulfate (male), GGT, lead, leptin, lipase, prolactin, rheumatoid factor, free T4, free T3, urine albumin/creatinine ratio, urine albumin (microalbumin), PSA (male), and progesterone (female).

Partially SupportedSunlight contains 3-5% UVB radiation, while some high-priced tanning beds may contain very little.

Partially SupportedAnhedonia is an indicator of brain inflammation and is connected with brain insulin resistance.

Well SupportedFasting insulin is considered the single most important test among blood work markers.

Not SupportedThere is no solid evidence that TMAO is harmful to humans, and the association with choline and meat consumption is questionable.

Partially SupportedSSRIs may affect neurotransmitter levels long-term.

Not SupportedSome spring waters may contain contaminants such as PFAS, arsenic, and pfas.

Partially SupportedThe APOE4 genotype is likely not a cause for concern for individuals who are insulin sensitive.

Partially Supported25-hydroxy vitamin D and a CBC with differential are recommended blood tests.

Not SupportedNootropic supplements like huperzine A are not recommended due to concerns about long-term effects on neurotransmitter levels and brain adaptation.

Partially SupportedDepression is often an autoimmune condition in the brain driven by neuroinflammation, which can be addressed by healing the gut and removing inflammatory triggers.

Partially SupportedAdding beef organs to the diet can improve mood and mental clarity.

Partially SupportedDuring winter months in Seattle, from November to March, significant vitamin D production in the skin from UV light is unlikely.

Partially SupportedTMAO is not a concern for humans.

Partially SupportedA 2022 review found no consistent evidence for a serotonin deficiency causing depression, and suggested long-term antidepressant use might reduce serotonin concentration.

Partially SupportedHydration needs vary based on environmental factors like humidity and personal factors like fruit intake.

Not SupportedThe speaker avoids exogenous interventions like nicotine and nootropics, preferring to influence neurotransmitters through diet.

Not SupportedSSRIs, SNRIs, and dopamine-norepinephrine reuptake inhibitors may not address the root cause of depression, which is likely neuroinflammation stemming from gut issues.

Partially SupportedTriglyceride levels are not associated with Alzheimer's disease risk in individuals without the APOE4 allele.

Partially SupportedIn the Tsimane population, APOE4 carriers showed less inflammation and lower propensity toward dementia and cognitive decline.

Partially SupportedIn insulin-sensitive individuals, saturated fats from animal foods and red meat may be protective against dementia long-term.

Partially SupportedSerum folate, B12, RBC magnesium, and uric acid are recommended blood tests.

Not SupportedPhysicians should not push back against patients requesting blood work to understand their own physiology.

Partially SupportedIndividuals consuming a vegan diet had the highest serum uric acid concentrations compared to meat-eaters, fish-eaters, and vegetarians in the EPIC-Oxford cohort study.

Not SupportedUse liposomal glutathione cautiously and only short-term for specific toxic exposures, not for long-term daily use or for bile health.

Partially SupportedAPOE4 genotype may increase dementia risk, potentially mediated by insulin resistance.

Partially SupportedThe APOE4 variant is not a clear predictor of Alzheimer's or dementia in humans, with nuance not fully communicated.

Not SupportedLong-term glutathione supplementation can stress human biochemistry due to its breakdown products, including cysteine.

Limited ResearchLow-dose glyphosate exposure in humans may contribute to steatohepatosis and non-alcoholic fatty liver disease.

Partially SupportedA lower IGF-1 z-score may indicate a longer lifespan.

Partially SupportedHigh carbohydrate intake from fruit and honey can improve electrolyte status and muscle fullness.

Partially SupportedPrefer Airbnbs with grills when traveling to simplify cooking and avoid non-stick cookware.

Partially SupportedIndividuals living above Phoenix, Arizona, may experience a 'vitamin D winter' where their skin cannot produce vitamin D from sunlight due to the low angle of the sun.

Not SupportedLong-term use of substances affecting neurotransmitters like nicotine, acetylcholinesterase inhibitors, and ADHD medications may have negative long-term effects on the brain.

Partially SupportedIn insulin-sensitive populations not consuming processed diets, the APOE4 variant is protected and not a clear predictor of Alzheimer's or dementia.

Partially SupportedDesiccated or fresh testicle, kidney, spleen, and pancreas may help increase testosterone in males.

Partially SupportedAPOE4 is associated with an increased risk of dementia, specifically Alzheimer's.

Partially SupportedAn animal-based diet is preferred over vegan, paleo, or Mediterranean diets.

Partially SupportedMany water samples in Italy contained higher levels of glyphosate than the tolerable limit for pesticides in drinking water (0.5 micrograms per liter).

Not SupportedConsuming excessive amounts of fruit and honey can prevent adequate intake of meat and organs in an animal-based diet.

Partially SupportedIndigenous populations avoiding seed oils and processed sugar show less propensity toward dementia and cognitive decline.

Partially SupportedPreparing food ahead of time, using glass containers, and shopping in advance are necessary for maintaining an animal-based diet when traveling.

Partially SupportedHydration needs vary based on environment and activity level.

Partially SupportedA comprehensive liver health panel should include ALT, AST, alkaline phosphatase, bilirubin, albumin, total protein, globulins, and the albumin-to-globulin ratio.

Partially SupportedAn IGF-1 z-score of -0.5 indicates a value half a standard deviation lower than the general population mean.

Partially SupportedA comprehensive kidney health panel should include creatinine, eGFR, BUN, and albumin.

Partially SupportedUric acid is a blood marker that should be included in a comprehensive panel.

Partially SupportedMinimizing exposure to toxins, such as glyphosate, is a good step toward optimal long-term health.

Partially SupportedThe human body has a system in the kidney that effectively eliminates excess uric acid when it is produced.

Not SupportedNicotine and other acetylcholinesterase inhibitors can be difficult to discontinue and may negatively impact brain function.

Partially SupportedGenetic testing for APOE4 can be obtained through a physician or services like 23andMe.

Partially SupportedKellogg's Corn Flakes and All-Bran Plus Sticks contain significant amounts of glyphosate (0.14 mg/kg).

Partially SupportedHoney is considered valuable and has demonstrated benefits.