Paul Saladino· MD
many fish have preformed levels of TMAO that are 40 times higher than what would be observed to be formed from an equivalent amount of choline and carnitine in the similar amount of meat from red meat
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The evidence is convergent. Multiple independent sources reach the same conclusion, the underlying mechanism is well-characterized, and even the field's most cautious voices treat it as worth doing.
many fish have preformed levels of TMAO that are 40 times higher than what would be observed to be formed from an equivalent amount of choline and carnitine in the similar amount of meat from red meat
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you know bad pun for a while because fish has not been associated with cardiovascular disease historically in epidemiology studies and yet fish has 40 times more preformed TMAO
there's more preformed tmao in fish fish doesn't associate with problems
when you can get more pre-formed tmao by eating fish than you could by eating an equivalent amount of red meat
there is more tmao in many fish preformed than you would get from an equivalent amount of meat based on the choline and carnitine in the meat but fish has never been associated with negative cardiovascular outcomes
an equivalent amount of fish contains more pre-formed tmao than the same amount of red meat that has choline and carnitine that would make tmao in your gut
my recollection is that I brought the fish up because my argument was it's really easy to just look at this stuff and say and repeat what we already believed about eggs and red meat bad for you and if you isolate it to that it kind of makes a clean story but it makes a really bad story if you bring fish into the equation because fish have so much TMAO that you're probably literally getting hundreds of times more TMAO exposure when you eat fish than when you eat those foods so my point was always how can you not bring fish into the discussion