Audit a URL →

Sign in Sign up free

Loading…

Weekly · Sunday Morning

Five longevity claims.
Worth your time.
Every Sunday.

Last Sunday

Rapamycin extends mouse lifespan 9–14%
NAD+ precursors reverse aging in humans
Blue-light glasses improve sleep quality
Walking 10 min after meals blunts glucose
Verdict change — caffeine half-life downgraded

5 audits·1 verdict change·0 affiliate links·Every Sunday

Joining 1,247 readers — founders, MDs, and longevity-obsessed people who fact-check their own health decisions.

Browse

Decisions Claims Content Creators

Product

Audit a URL Sunday roundup API (soon)Pricing

About

FAQ Methodology Editorial Standards Corrections Press & brand RSS feed

Legal

Terms of Service Privacy Policy DMCA

Finally, something serious in this space.
Because we actually read the papers.

© 2026 Whalespan. Independent, evidence-graded longevity.

TMAO is not a problem for humans — Whalespan

Content›Video›TMAO is not a problem for hu…

TMAO is not a problem for humans

Paul Saladino4m · 2022-09-12

Claims Made

8

Claims Supported

7

Support Rate

88%

Support rate

7 of 8 claims supported

7 supported1 partial / not

Claims from this content

8

✓Well SupportedFish contains significantly higher preformed TMAO (40x more) than historically associated with cardiovascular disease.✓Well SupportedChicken and pigs accumulate polyunsaturated fatty acids, including seed oils and corn/soy derivatives, in their tissues.✕Not SupportedTMAO (trimethylamine N-oxide) has not been shown to be causally problematic for humans regarding cardiovascular disease.◐Partially SupportedStudies suggesting meat is associated with negative cardiovascular outcomes may be influenced by confounding factors like healthy user bias or unhealthy user bias.Partially Supported

Discussion

Native comments, Twitter mentions, and Reddit threads about this content — surfaced together so the conversation isn't fragmented across platforms.

M

Share your read of this content…

Posting publicly as you · linked to your social profiles

Sort by:

AV

A. Volkovreader

4h

Bookmarking — the dossier-vs-overview split is the right call. Most of the time I want overview; sometimes I want receipts.

NP

N. Park

2d

Would love a "what would change this verdict" RSS feed. Sign me up if it exists.

◐

Plasma TMAO and TML did not modify the effect of total choline intake on acute myocardial infarction risk in patients with stable angina pectoris.

◐Partially SupportedSubstances like carnitine and choline, precursors to TMAO, are essential for brain function, hormones, libido, energy, and testosterone.

◐Partially SupportedType 2 diabetes and kidney disease increase TMAO levels because the kidneys retain TMAO when they do not function properly.

◐Partially SupportedTMAO has good specificity for fish intake, indicating that high TMAO levels in cohorts often reflect high fish consumption.