Problems with APOE4 and saturated fat from animals would have been disadvantageous throughout human existence.

“in fact the hypothesis the premise that I advanced in the book is that it was eating meat that made us human so to suggest that there is an evolutionary mismatch between eating meat and a belief or doesn't really make sense evolutionarily speaking in terms of our history”

“the e4 allele is associated with an increased age-related disease risk but also the ancestral form so we must ask ourselves was apoe4 not advantageous to us for millions of years of human evolution and hundreds of thousands of years of evolution as homo sapiens during which we were very likely seeking out treasuring and celebrating saturated fat from animals and animal fats”