Paul Saladino· MD
it's important to know that apoe4 is the ancestral genotype of apoe is an april of a protein present in our bodies and apoe4 is what all of our primate ancestors had and what all of humans and pre-hominids had for millions of years
The headline is broadly defensible, but the qualifications matter. Effect sizes vary by population, the strongest claims rest on shorter trials, and credible voices push back on how it's typically framed.
it's important to know that apoe4 is the ancestral genotype of apoe is an april of a protein present in our bodies and apoe4 is what all of our primate ancestors had and what all of humans and pre-hominids had for millions of years
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Native comments, Twitter mentions, and Reddit threads about this claim — surfaced together so the conversation isn't fragmented across platforms.
Bookmarking — the dossier-vs-overview split is the right call. Most of the time I want overview; sometimes I want receipts.
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the e4 allele is associated with an increased age-related disease risk but also the ancestral form
the original quote unquote original human apoe a genotype was apoe4 and it had it it compared to the others which came along later is often associated with a greater or heightened immune response in in certain settings so this is maybe beneficial when you're being exposed to a greater or number or different um insults than you may be based on the habitat that you're you know previously evolved in