The evidence is convergent. Multiple independent sources reach the same conclusion, the underlying mechanism is well-characterized, and even the field's most cautious voices treat it as worth doing.
there are at least three deterministic genes in Alzheimer's disease uh one is called psn1 another one is called pn2 and another one is called AP those genes collectively make up about 1% of cases of people with Alzheimer's disease
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if you get those genes you get alzheimer's that's that's what the books say
about one percent of cases of alzheimer's disease do seem to be genetically predetermined so there are three genes psen1 psen2 and app that make up about one percent of cases of alzheimer's disease
so these these three genes are as close to what we would call deterministic as any genes are unfortunately they're very uncommon okay so the three genes we're going to talk about which I'm not going to say much about them other than to State what they are one is psen1 psen2 and app so those three genes collectively account for one percent of patients with Alzheimer's disease