The evidence is convergent. Multiple independent sources reach the same conclusion, the underlying mechanism is well-characterized, and even the field's most cautious voices treat it as worth doing.
but people old people especially they aren't sleeping you get these amyloid proteins that are up there and if you're not going to good sleep they're not getting cleaned out you got a you have a vicious cycle between diet sleep and build-up plaques in your brain that is just just you're just doomed
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on just one night of poor sleep levels of amyloid in cerebrospinal fluid increased by 30 percent and tau by 50 percent so this is a major like increase in these proteins and it's thought that having more of them around increase the susceptibility of them to miss fold and ultimately clump together and form these these plaques
if you're getting less sleep at almost any point in the life span the risk that you're going to have higher amounts of these Alzheimer's disease proteins in your brain is greater
the fact that sleep already let's just call outsider's disease this strange heterogeneous sort of mix right now that we feel uncomfortable about in terms of pinning one exact pathological ingredient as the causal trigger for that in fact I actually probably think Tao is if you look at the data I think the data are better on them in terms of predicting cognitive decline at least then amyloid is but the fact that you know we've now found that insufficient sleep will also lead to tower aggregation - I think it is concerning the morning
one of the things we talked about on our podcast was a single night of mist sleep would alter the brain's ability to clear amyloid or maybe it was towel but something that was sort of toxic to the brain and you could document this by doing lumbar punctures on patients pre and post
Poor sleep boosted levels of amyloid beta (biomarker linked to Alzheimer's) by 25-30% in participants.
Adults that were subjected to sleep deprivation for 36 hours experienced a 50% increase in a protein called tau that is linked to neuronal cell death and Alzheimer's disease.
People that have their deep sleep cycle disrupted for one night experience a 10% increase in amyloid plaque levels.
A preliminary study found one night of sleep deprivation in healthy young men caused a 17% increase in the blood level of tau, a protein that forms tangles in the brain and is linked to Alzheimer's disease.
One night of sleep deprivation in 20 healthy subjects led to a 5% increase in amyloid beta plaques in brain regions that play a role in the early stages of Alzheimer's disease.