Synthetic estrogen metabolites from some anabolic compounds have less predictable activity at the estrogen receptor compared to natural estrogen.

“even then you get these synthetic estrogen metabolites that have less predictable activity so for example dball converts to like methyl estradi which the potency of it at the estrogen receptor it's it's not as predictable and your body doesn't really know exactly it it doesn't have as predictable of outcomes in terms of providing the base layer of what you want from like a broadspectrum perfectly balanced androgenous converts to estrogen where you wanted in tissues you know it protects the brain to some extent”