CBD may benefit sleep through thermoregulation, anxiolysis, and modulation of adenosine signaling.

“The first is that it's thermo regulatory. And what we found in some animal models is that CBD will create a profile of hypothermia. In other words, it cools the body the core body temperature down. And that's something that we know is good for sleep. The second is that it's an anxyolitic, that it can reduce anxiety. And that data is actually quite strong, even with some functional imaging work that's been coming out recently showing that one epicenter of emotion called the amygdala deep within the brain is quietened down with CBD. So I think that's at least a second non mutually exclusive. I think the third is some recent data that's come out that was suggesting that CBD can alter the signaling of adenosine.”