Sleep deprivation can lead to an exponential rise in anxiety, with individuals reaching diagnostic thresholds for anxiety disorders after prolonged wakefulness.

“I can within one single night of sleep loss I can put someone who is non clinically anxious to a level of anxiety where they would have a clinical anxiety disorder diagnosis that's how quickly it can happen”

“some you know come on tap later in the sleep deprivation others very very quickly essentially what we're trying to ask is what is the recycle rate of a human being and after about 16 hours of wakefulness things start to go wrong and the things that start to go wrong soonest and perhaps most severely one of those things certainly is your mental health anxiety being one of the mood being the other depression”

“A single night of sleep deprivation increased anxiety levels by 30% in healthy young adults.”

“Anxiety goes up. We've done the dose response curve. We've looked, you know, hour by hour by hour. And as soon as you get past probably about 14 or 15 hours of wakefulness, anxiety starts to increase.”