Atherosclerosis progresses over decades, with APOB being a major driver alongside hypertension, smoking, and insulin resistance.

“so atherosclerosis begins at Birth um when you do autopsies on people who are very young in fact I in the book include a photo of a guy who you know a man I forget I think maybe 26 years old who was a victim of a homicide or something so an completely unrelated death um but you look at the autopsy sections of his coronary arteries I mean he already had very Advanced artherosclerosis”