Apolipoprotein B (ApoB) is causally linked to atherosclerotic cardiovascular disease (ASCVD).

“when you have causal things that cause disease you eliminate them and the analy I use is cigarettes with lung cancer so nobody disputes that cigarettes are causally linked to lung cancer they are it's as clear as you know Tuesday follows Monday but people forget that you know causality doesn't mean everybody who smokes will get lung cancer and it doesn't mean that every person with lung cancer um smoked so you you don't need to be necessary and sufficient necessary or sufficient to still be causal but our approach to patients who smoke is very clear which is Never Smoke and if you do smoke stop immediately do we look at people who smoke and say well once your 10year risk of lung cancer reaches this threshold we're going to tell you to stop smoking or once your pack year smoking is above the 50th percentile or the 80th percentile we're going to tell you to stop absolutely not you immediately eliminate smoking and so similarly it makes no sense that we would look at a causal driver of asbd in the case of apob and kind of take an approach of well being at the 20th percentile or the 30th percentile the 40th percentile is acceptable”