The evidence is convergent. Multiple independent sources reach the same conclusion, the underlying mechanism is well-characterized, and even the field's most cautious voices treat it as worth doing.
So unfortunately most physicians don't know what Lp[a] is, and yet somewhere between eight and 12% of the population has a high enough, and depending on who you, you know, I had a recent guest on my podcast who suggested it could be as high as 20%, have a high enough Lp[a], that it is contributing to atherosclerosis.
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Bookmarking — the dossier-vs-overview split is the right call. Most of the time I want overview; sometimes I want receipts.
Would love a "what would change this verdict" RSS feed. Sign me up if it exists.
LP little a is another- Yeah, yeah, he's another actor. He is a special type of LDL that, again, in sort of 10 to 20% of the population, is a really bad actor.
Assuming that they can afford it or their insurance can cover it. - Yeah, I mean, look, I certainly think everybody should be screened early in life because if you look at, like, what's the single most prevalent genetic driver of atherosclerosis, is Lp[a].
So unfortunately most physicians don't know what Lp[a] is, and yet somewhere between eight and 12% of the population has a high enough, and depending on who you, you know, I had a recent guest on my podcast who suggested it could be as high as 20%, have a high enough Lp[a], that it is contributing to atherosclerosis.
elevated Lp(a) is much more common as a genetic cause of heart disease, maybe 10-20x more common.
directionally one in ten people listening to this podcast has an elevated lp little a and it represents unless you correct me tom i believe it would represent the single greatest genetic driver of atherosclerosis