Type 3 dyslipoproteinemia involves relatively few particles but very large and cholesterol-rich VLDL particles, which contribute to its dangerous nature.

“the normal metabolism is the vldl particles get broken down sequentially as the triglyceride is removed and they get converted to ldl particles some of them are removed by the liver along the way in type 3 that process breaks down and for reasons that are not well understood on the age of 30 35 or 40 people develop high triglycerides and high cholesterol because the vldl particles aren't being broken down to ldl particles that process stalls those particles circulate a long time in the blood and while they're circulating cholesterol gets deposited into them so they become very cholesterol rich like really really cholesterol rich and those people have a very high risk of coronary disease peripheral vascular disease”