Peter Attia· MD
so the phenotype of that patient is that they have relatively few particles but they have so much cholesterol because the vldls are so large and so cholesterol full yeah that's right
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The headline is broadly defensible, but the qualifications matter. Effect sizes vary by population, the strongest claims rest on shorter trials, and credible voices push back on how it's typically framed.
so the phenotype of that patient is that they have relatively few particles but they have so much cholesterol because the vldls are so large and so cholesterol full yeah that's right
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the normal metabolism is the vldl particles get broken down sequentially as the triglyceride is removed and they get converted to ldl particles some of them are removed by the liver along the way in type 3 that process breaks down and for reasons that are not well understood on the age of 30 35 or 40 people develop high triglycerides and high cholesterol because the vldl particles aren't being broken down to ldl particles that process stalls those particles circulate a long time in the blood and while they're circulating cholesterol gets deposited into them so they become very cholesterol rich like really really cholesterol rich and those people have a very high risk of coronary disease peripheral vascular disease