Atherosclerosis begins developing in the third decade of life, with clinical events typically manifesting in the fourth decade.

“atherosclerosis begins at Birth um when you do autopsies on people who are very young in fact I in the book include a photo of a guy who you know a man I forget I think maybe 26 years old who was a victim of a homicide or something so an completely unrelated death um but you look at the autopsy sections of his coronary arteries I mean he already had very Advanced artherosclerosis now it wasn't clinically relevant it wasn't going to kill him anytime soon but the point is this is a disease that takes decades to progress”