Rhonda Patrick· PhD
so there was a systematic review and it was 2022 I believe um and these are all like we need this is this sparse data right a systematic review of the existing literature which isn't a huge body of evidence but um so there was a bunch of studies that looked at berberine and you know varying Doses and then looking at it in conjunction with statins or comparing it to statins or comparing it to a placebo and in it pretty much to me was convincing that it was beneficial in every in every single scenario so buring Al Bering alone was um lowering the LDL cholesterol and can't remember if it was particle number but it was and it's interesting berberine is also a mitochondrial toxin really yeah berberine is an analog of met foran so so it's a complex one inhibitor is it really wow I didn't know that it it was like it was to me looking really beneficial where it was like I'm not saying that wouldn't be I I'm just sort of pointing out like it's interesting is there literature showing that or is it like a inv vitro kind of thing where it's like I don't remember it's been so long since I've looked at berberine but um but you know berberine is kind of a poor man's met Foreman okay well it was and that's the way I thought about it I think I'd heard you talk about it years ago maybe on Tim's podcast I don't remember it was a long time ago and that's kind of where I even first heard of berberine with you and um I remember cuz I was like going for a run it was when I lived in Oakland and then I was like bbin what's that and I remember you talking about in the context of I think metabolic Health y y and should um this data on the lipids was very interesting and I link yeah what was the magnitude of effect I don't like you the doc it's in that document it's linked the studies the meta analysis so you can look at it cuz I don't remember everything and but what I do know is it also lowered the side effects of Statin myopathy Al was one in particular um it lowered the dose effective dose of statins that was needed to you know lower the LDL cholesterol very interesting right