Epigenetic age may reflect changes over years rather than weeks or months, and its sensitivity to immediate factors like vitamin D or glucose levels makes it volatile and not clinically useful in its current form.

“it may be so i'm actually fairly impressed by the epigenetic data but maybe it's not going to work in the short term like that it may be this may be something that tells you something over the course of years but not over the course of weeks or months i think my only point there is that it's very sensitive to what's happening in the moment right and so when when i look at a lot of these aging clocks and i look at the inputs i i think to myself these are very easy to manipulate what was your vitamin d level on this day what was your glucose level at the moment of that blood test what i mean these things are so easy to manipulate and they have so much volatility over time that i don't find them to be clinically quite useful”