A normal resting EKG may not reveal cardiac issues detectable only under stress, similar to how a normal resting RQ may mask underlying mitochondrial dysfunction.

“We want to see the same thing that is done usually at the EKG level. So when a cardiologist wants to study the heart, if there's any abnormality, resting EKG has a reliability of about 50%. So you could see some red flags already, but you don't see everything. You have to stress the heart to see something. Exactly. And you stress the heart and similar protocol than what we did here. And that's what you do when you do EKG in stress, right, situations. The reliability is about 95%, 97%. So you see a lot of things. So I decided to take the same approach and say, okay, now at rest, as you very well said, you see people in the 90s with RQ, right? And that's our red flag now. Okay, let's trace those mitochondria, right? So in other words the analogy is sometimes you'll do an EKG on somebody at rest and you'll see changes in the ST Segment that tell you immediately there's a problem But there are many people who have a normal resting EKG But only when you put them on the treadmill and make them run Do you see that change in the electrical signal that tells you there's a problem?”