Peter Attia· MD
One would be if you had a man whose prostate volume was 80 grams, that's big, and his PSA was four, well, that's a low ratio. That's something called PSA density, how much PSA is made per gram of tissue.
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The evidence is convergent. Multiple independent sources reach the same conclusion, the underlying mechanism is well-characterized, and even the field's most cautious voices treat it as worth doing.
One would be if you had a man whose prostate volume was 80 grams, that's big, and his PSA was four, well, that's a low ratio. That's something called PSA density, how much PSA is made per gram of tissue.
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PSA density predicts likelihood that you'd ever be diagnosed with prostate cancer it predicts aggressiveness of a cancer If you're diagnosed with it and it actually predicts your outcome if you have a prostate cancer
so if your PSA is four and your prostates 40 gram which is about average size for a 60 65 year old guy that's a PSA density of 0.1 we know that that is correlated with a low risk of having an aggressive prostate cancer
what we look at is the rtio itio of the prostate the PSA value to the prostate volume and that as you alluded to is called PSA density and in general when I when I educate patients I tell them well we want a a PSA to be about 10% of the volume of the prostate or less to kind of be in a safe range so if your PSA is four and your prostates 40 gram which is about average size for a 60 65 year old guy that's a PSA density of 0.1 we know that that is correlated with a low risk of having an aggressive prostate cancer
so the higher your PSA density the more significant your disease will be so the faster it increases and the faster that your PSA Rises it is a canary in the coal mine to say hey you need to do some additional evaluation
the higher your PSA density the more significant your disease will be
what we look at is the ratio of the prostate the PSA value to the prostate volume and that as you alluded to is called PSA density and in general when I when I educate patients I tell them well we want a a PSA to be about 10% of the volume of the prostate or less to kind of be in a safe range
The second thing we want to consider is what's called PSA density. This is where you take the PSA and you divide it by the prostate volume. So if the PSA density, pardon me, if the PSA is measured in nanogs per deciliter, which it typically is, you divide that by the prostate volume in milliliters and you will get a number. If that number is large, typically over 0.15, we start to get a little bit concerned.