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Screening for prostate cancer (Qualy #53) — Whalespan

Content›Video›Screening for prostate cance…

Screening for prostate cancer (Qualy #53)

Peter Attia17m · 2020-02-14

Claims Made

24

Claims Supported

19

Support Rate

79%

Support rate

19 of 24 claims supported

19 supported5 partial / not

Claims from this content

18

✓Well SupportedPSA density is a predictor of prostate cancer diagnosis, aggressiveness, and patient outcome.✓Well SupportedFree PSA percentage, along with absolute PSA, PSA velocity, and PSA density, provides valuable information for assessing prostate cancer risk.✓Well SupportedIn men under 60, a PSA density greater than 0.1 or 0.12 may warrant a biopsy if the MRI shows no lesion.✓Well SupportedAdvanced PSA-based testing provides more detailed prostate health information than a standard PSA test.Well Supported

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Attia walks back the clinic protocol: too aggressive for healthy adults

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A. Volkovreader

4h

Bookmarking — the dossier-vs-overview split is the right call. Most of the time I want overview; sometimes I want receipts.

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2d

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✓

A PSA level above 2.5 ng/mL is abnormal for younger individuals and warrants further investigation.

◐Partially SupportedThe 4K score provides a percentile chance of being diagnosed with high-grade, aggressive, lethal prostate cancer.

◐Partially SupportedPSA levels can increase with prostate size and age.

◐Partially SupportedProstate-specific antigen (PSA) is a protein produced by the prostate gland that aids in the liquefaction of semen.

◐Partially SupportedA PSA of 6 in a 40-gram prostate raises red flags for potential prostate issues.

✓Well SupportedThere is a proportional rise in cancer detection with rising PSA numbers, though no single PSA number guarantees the absence of cancer.

◐Partially SupportedA 4K score below 1.5% indicates a 1.6% probability of dying from metastatic prostate cancer within the next 20 years.

◐Partially SupportedThe percentage of free PSA is a metric used to refine the specificity of the PSA test for cancer detection.

◐Partially SupportedProstate cancer can lead to increased PSA levels due to backflow into the bloodstream.

◐Partially SupportedThe 4K score, combining PSA, percent free PSA, intact PSA, and HK2, can discriminate between cancerous and benign prostate cells.

◐Partially SupportedThe Prostate Health Index (PHI) test uses minus two pro PSA to discriminate between cancerous and benign prostate cells.

◐Partially SupportedA biomarker cutoff of 7.5% is associated with a 16-17% chance of a cardiovascular event within 20 years.

◐Partially SupportedPSA is a biomarker for prostate size, not specifically for prostate cancer.

◐Partially SupportedA digital rectal exam could potentially increase PSA levels in the blood.