Paul Saladino· MD
I'm bummed that there is no good clinical test for circulating lipopolysaccharide if there were a way to test this I think we would have a very powerful metric
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The headline is broadly defensible, but the qualifications matter. Effect sizes vary by population, the strongest claims rest on shorter trials, and credible voices push back on how it's typically framed.
I'm bummed that there is no good clinical test for circulating lipopolysaccharide if there were a way to test this I think we would have a very powerful metric
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I'm bummed that there is no good clinical test for circulating lipopolysaccharide if there were a way to test this I think we would have a very powerful metric
The gut, yeah. Have you been looking...how long have you been doing this modified ketogenic diet? It, sort of, evolved from 2008 to '09, I started experimenting with it because that's when I got interested in using... Yeah, I've never really gotten out of ketosis. It's quite a long time. That's quite a long time. Yeah. If I did, I may have reverted back to, like, a low-carb Paleo which is maybe up to 40% to 50% fat or protein on some days. So I've been a little more liberal on the protein at times, but yeah, I've been following it for a long time. And I do blood work really consistent. Well, the reason I ask is because, it's the one, like I mentioned, I'm very interested in nutritional ketosis, which is why I'm excited to talk to you because you know so much more about it. And I'm trying to, like, get to the bot-,...there's this conflict in my head with eating a lot of fat and its effects on the gut because I know a lot of my gut researchers, a lot of my friends are, kind of, looking at gut health and one of the main things that you do induce endotoxin, which is released from bacterial cell membranes. I remember it's one of main things needed to induce gut permeability is if you have a high-fat diet. You feed mice, you feed...this is all done in animals, of course, which is... There's lots of problems with that, but... What's the typical fat source for that? Is it lard or is it...? A variety of different fat sources. There's lard, there's corn oil. I mean, so there's there's a variety of different fat sources, but fat itself in order to be digested, you have make these bile acids like deoxycholic acid, which which causes endotoxin release. It also acts as a surfactant. I mean, it's like a detergent. So, I'm not convinced that it's not not healthy, but I'm not...I'm, sort of, trying to get to the...there's a disconnect in the literature because there's so much information out there showing the benefits of a ketogenic diet, nutritional ketosis. Let me ask this question real quick. So when endotoxin is released from these bile acids, so there would be a predictable, a characteristic cytokine profile that would reflect that, right? Yes, so there's a cytokine profile and you also measure endotoxin in the blood, which is a very tricky thing to do because there's a lot of false positives and I know someone who's trying to develop an assay to make it actual-, because he's very OCD about it. It's not out there for clinical use yet because of that reason, and even doing it in animal studies, there's a lot of researchers that don't really do it right, measuring endotoxin.