Peter Attia· MD
historically a lot of you know most of the reviews and textbooks would argue that it's largely apoptosis that does that because in apoptosis of course there is a laddering of the dna or chopping up of the dna
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The evidence is convergent. Multiple independent sources reach the same conclusion, the underlying mechanism is well-characterized, and even the field's most cautious voices treat it as worth doing.
historically a lot of you know most of the reviews and textbooks would argue that it's largely apoptosis that does that because in apoptosis of course there is a laddering of the dna or chopping up of the dna
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the complicating factor is now we have a much better understanding that there's also dnases just floating in the plasma that are also chopping up dna so over a long chunk of dna we're released through a non-apoptosis process it would likely also become chopped up and so you know we can't do just because it's chopped up assume it comes from apoptosis
we think it's likely multifactorial apoptosis necrosis you know basically any way that a cell can die and release some of its contents into the blood
when cells um are destroyed right either through necrosis or apoptosis or just you know there's a lot of cell turnover right of cells that replicate right especially epithelial cells blood cells um and so on um um as those again as the kind of natural biochemistry destroys them some of the