We can't find evidence that holds up here. Proponents are reasoning from mechanism or analogy rather than direct human data, and the most credible skeptics raise objections we can't dismiss.
So I realize that's a mouthful. Just to be very clear, if you wake up and you ingest caffeine right away, you're blocking the adenosine receptor, but you're not clearing it out. You're also preventing cortisol from having its normal increase and rise such that it can directly clear out adenosine because cortisol can clear out adenosine.
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what happens if you do that is there's an accumulation, a sort of glut of adenosine that hangs around. And then in the afternoon, when the effects of that caffeine start to wear off, you will experience the so-called afternoon crash.
If, however, you were to wake up and immediately drink caffeine-- caffeine itself can stimulate the release of cortisol a little bit more than it would otherwise be present in your system. But by blocking those adenosine receptors and because of the indirect effects of caffeine on the cortisol system, you actually are reducing the clearance of adenosine that would otherwise occur.
And actually this is also why uh I don't recommend that people caffeinate as soon as they wake up. I recommend people wait an hour because if if you caffeinate as soon as you wake up, the the amount of adenosine that that caffeine is blocking is still very low. You haven't produced enough yet to really have much of an effect. But if you drink caffeine as soon as you wake up in the morning and you feel more alert, it's probably your sleep inertia naturally coming down and your melatonin naturally getting blocked and you're feeling the effects of it and you're attributing it to the caffeine when actually you could have skipped the caffeine.