The evidence is convergent. Multiple independent sources reach the same conclusion, the underlying mechanism is well-characterized, and even the field's most cautious voices treat it as worth doing.
It does appear that caffeine can not only indirectly stimulate IGF-1 and the antigen phase of hair cell growth by way of reducing PD and TGF beta. But it also seems to reduce apoptosis which is naturally occurring cell death of that stem cell niche.
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Native comments, Twitter mentions, and Reddit threads about this claim — surfaced together so the conversation isn't fragmented across platforms.
Bookmarking — the dossier-vs-overview split is the right call. Most of the time I want overview; sometimes I want receipts.
Would love a "what would change this verdict" RSS feed. Sign me up if it exists.
and by ingesting caffeine, or by applying topical caffeine ointment or cream to the scalp, you can suppress PDE sufficiently enough to increase IGF-1 and increase some hair growth, or at least maintain hair growth in that region.
appears that caffeine can offset the death of that niche and potentially maintain the stem cell population longer, making caffeine a really good choice to think about in conjunction with the various chemical treatments aimed at directly attacking the DHT pathway that we'll talk about next.
One of the things that caffeine does is it is a fairly potent PDE inhibitor. By being a potent PDE inhibitor, it indirectly stimulates IGF-1.