Rhonda Patrick· PhD
So it's kind of more like... But you have to individually house the animals, and then, you know, sometimes if you house them together, they'll start, like, fighting and eating each other because they're kind of hungry. But one thing that we saw very consistently early on is that a mild amount of calorie restriction makes these mice like super mice. Like they become...you know, they're thinking faster. They are really thriving in the context of a calorie deficit, and I think that goes back to human evolution too. So, we survive today because we undoubtedly experience food scarcity and limited food availability, and in the context of being hungry, that enhanced our cognition and even exercise performance to be able to acquire resources, right? So the same thing I think is happening in their mice, and it could be... I have to look at the weights of the mice, but a lot of it's kind of like weight dependent and producing that energy deficit. But you just get a whole plethora of things to happen in regards to suppressing age-related chronic diseases with just a little bit of dietary restriction seems to unmask this probably because, with a standard rodent chow-fed ad libitum, they overeat, and it just basically fuels metabolic derangement that contributes to early-onset age-related chronic diseases and also the formation of spontaneous tumors.