now when you continue to have this damage over time there's a constant flow of this damage occurring every day and often it takes several decades but eventually you may acquire a mutation in that very important tumor suppressor Gene therefore in activating that tumor suppressor Gene so it's non-functional when that happens any future damage that occurs will not have that cellular protective pathway activated and so what ends up happening is that DNA damage ultimately will lead to the growth both of abnormal cells because they will not be they will not be killed by tumor suppressor genes in fact over 50% of adult carcinomas are associated with nonfunctional tumor suppressor Gene called p-53