I think I was able to keep it in the book I know there's always so much pressure you're trying to chop stuff out of the book so I don't remember if this finally made it in but I at least referenced one study that had taken patients I think with lung cancer who were you know none of them had any pd1 activity and then a course of platinum based chemotherapy all of a sudden rendered a subset of them to now be susceptible to it in other words using a conventional chemo increased immunosusceptibility even the conventional chemo itself wasn't particularly responsive