the second big reason is that we learn while giving this Neo adant treatment how well the tumor responds and if the cancer totally disappears intuitively obvious that's a really favorable prognostic finding and we call that a pathologic complete response it just means the pathologist looks under the microscope at the end of that treatment course at the time of the surgery and says there's no cancer left that's a really good finding and puts the patient into a much lower risk category a much better prognostic group