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Rapamycin extends mouse lifespan 9–14%
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Navigating the treatment for breast cancer | Peter Attia & Harold Burstein — Whalespan

Content›Video›Navigating the treatment for…

Navigating the treatment for breast cancer | Peter Attia & Harold Burstein

Peter Attia19m · 2023-11-07

Claims Made

41

Claims Supported

33

Support Rate

80%

Support rate

33 of 41 claims supported

33 supported8 partial / not

Claims from this content

34

✓Well SupportedVaginal estrogen therapy is safe for women with a history of breast cancer and should be considered during perimenopause and menopause.✓Well SupportedImmunotherapy with checkpoint inhibitors like pembrolizumab shows significant activity in triple-negative breast cancer.✓Well SupportedHER2-positive breast cancer is now one of the most successfully treated types due to therapies like trastuzumab and pertuzumab.✓Well SupportedGenomic tests can help determine if chemotherapy is necessary for estrogen receptor-positive breast cancer, potentially allowing many women to avoid it.Partially Supported

More from Peter Attia

Peter Attia on Zone 2 Cardio

Peter Attia on Rapamycin (with Matt Kaeberlein)

Attia walks back the clinic protocol: too aggressive for healthy adults

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A. Volkovreader

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Bookmarking — the dossier-vs-overview split is the right call. Most of the time I want overview; sometimes I want receipts.

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◐

Chemotherapy drugs like doxorubicin, taxanes, and alkylating agents target dividing cells.

◐Partially SupportedAnti-estrogen therapies have saved more lives globally than bone marrow transplant, gleevac, or immunotherapy.

◐Partially SupportedRadiation therapy is used to sterilize the breast and chest area after surgery, and most women will require some form of drug treatment to prevent recurrence.

◐Partially SupportedMost women aged 70 and younger with early-stage breast cancer who are vigorous and healthy are advised to receive radiation therapy for local control.

◐Partially SupportedEarly detection via mammography has reduced breast cancer mortality by approximately half over the past 30-40 years.

◐Partially SupportedFor ER-positive, HER2-negative breast cancers, anti-estrogen medicines like tamoxifen or aromatase inhibitors are the most important drug therapy.

◐Partially SupportedTaking testosterone is unlikely to cause prostate cancer to develop from scratch in individuals without pre-existing cancer cells.

◐Partially SupportedNeoadjuvant therapy is used for larger tumors to shrink them, reduce lymph node burden, and tailor subsequent treatment based on observed response.

◐Partially SupportedOvarian suppression is used in younger women with ER-positive breast cancer to prevent recurrence by inducing menopause.

◐Partially SupportedSupportive care in oncology has improved with effective anti-nausea medicines, drugs to boost white blood cells, and cold caps to reduce hair loss during chemotherapy.

◐Partially SupportedThe pathological response observed after neoadjuvant therapy is a strong prognostic indicator for cancer patients.

◐Partially SupportedAromatase inhibitors work only in postmenopausal women by blocking estrogen production in non-ovarian tissues.

◐Partially SupportedTrastuzumab (Herceptin) improved outcomes for HER2-positive early-stage breast cancer.

◐Partially SupportedNon-hormonal options are available and effective for treating osteoporosis, hot flashes, night sweats, and genital symptoms in breast cancer patients.

◐Partially SupportedSide effects of anti-estrogen therapy include hot flashes, night sweats, bone and joint stiffness, hair thinning, vaginal dryness, increased UTIs, and osteoporosis.

◐Partially SupportedFor ER-positive metastatic breast cancer, anti-estrogen therapy is typically indefinite.

◐Partially SupportedMen with surgical prostate cancer can resume testosterone replacement therapy if PSA levels remain low.

◐Partially SupportedA complete pathological response to neoadjuvant therapy indicates a favorable prognosis and a lower risk category for the patient.

◐Partially SupportedCDK4/6 inhibitors are oral targeted drugs used to slow tumor proliferation in high-risk breast cancers.

◐Partially SupportedFor HER2-positive breast cancer with residual disease after neoadjuvant treatment, using trastuzumab emtansine improves prognosis.

◐Partially SupportedIn prostate cancer, testosterone acts as a growth factor for existing cancers, making androgen deprivation therapy the standard of care for metastatic disease.

◐Partially SupportedAdjuvant therapies are treatments given after surgery to prevent cancer recurrence, used in breast cancer, colon cancer, sarcomas, and prostate cancer.

◐Partially SupportedNeoadjuvant therapy is given before surgery to shrink tumors and provide systemic treatment.

◐Partially SupportedTamoxifen blocks estrogen's ability to reach the estrogen receptor in cancer cells.

◐Partially SupportedIn rare cases, women with breast cancer may require oral hormone replacement therapy for quality of life if they are severely uncomfortable without it.

◐Partially SupportedCurrent practice frequently avoids chemotherapy for most ER-positive breast cancers, including node-positive cases, based on genomic testing, contrary to 1999 NCI recommendations.

◐Partially SupportedTraditional chemotherapy drugs are typically IV medicines with side effects including nausea, hair loss, lowered blood counts, and fatigue, though supportive care has improved.

◐Partially SupportedTumor hormone sensitivity is inversely related to chemotherapy effectiveness.

◐Partially SupportedAnti-estrogen therapy and HER2-targeted therapy are distinct from traditional chemotherapy.

◐Partially SupportedAnti-estrogen medications are recommended for over 80% of breast tumors that are estrogen receptor positive.