so knowing that chemotherapy which is the earliest form in the of of drug in the modern arsenal against cancer says how can we kill a cell that is not responding to cell cycle signaling and the the first shot across the bow is well let's just kill anything that's dividing because we know that normal cells are less likely to be dividing and cancer cells are more likely to be dividing so let's target different cycles of the dna proliferation phase and that's why of course most people who are getting chemotherapy have side effects to the normal tissues that relate to that so the mucosal ulcers the hair loss the you know skin damage nail thinning all of that stuff is because those are tissues even though they're normal that are dividing more rapidly and they're being you know smacked as part of the collateral damage