Melanoma has a high unmet need and is characterized by a 50% frequency of BRAF mutations.

“I had decided melanoma was a cancer of terrible unmet need. interesting biochemistry insights coming from the previous couple decades, very strong lab-based science in melanoma at Penn where I was choosing to put myself on the clinical frontier, clinical research frontier. This aha moment in this paper was that 8% of cancers had BRF mutations, but the cancer type that most commonly had them in that paper, later paper described that there's one rare cancer that more commonly has BRF mutations, was melanoma at 50%. And the vast, vast majority of those mutations affected a single point in the gene.”