from zero to a billion cells we're pretty much flying blind
The evidence is convergent. Multiple independent sources reach the same conclusion, the underlying mechanism is well-characterized, and even the field's most cautious voices treat it as worth doing.
from zero to a billion cells we're pretty much flying blind
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Bookmarking — the dossier-vs-overview split is the right call. Most of the time I want overview; sometimes I want receipts.
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you have everything shy of a billion cells is by conventional detection methods undetectable right and then but but you know outside of the most rare tumors anything at a centimeter is not posing a direct threat to the organism
but for the most part if you talk about a lung cancer liver cancer pancreatic cancer colon cancer etc breast cancer one centimeter is irrelevant
so that's great question and uh you know the general sort of rule of thumb is that's about a billion cells already
Whole-body MRI screening in healthy adults produces more incidentaloma harm than cancer-mortality benefit.
Starting colonoscopy screening at 45 (vs 50) prevents enough early-onset cancers to justify the population cost.
Multi-cancer liquid-biopsy tests like Galleri detect early cancers at a stage that meaningfully improves survival.