prior to this one immunotherapy had found some efficacy which was trying the exact opposite strategy rather than blocking the inhibitor it was throwing more accelerant at the fire which was giving something called inter Lucin 2 so interlukin 2 is for lack of a better word candy and fuel for te- cells so the idea was if we have te- cells that innately recognize a cancer antigen can we just give high doses of interlukin 2 and have them undergo proliferation and response and the answer turned out to be yes but only in two cancers melanoma and kidney cancer and only at very small levels about 10% of the population would respond to these things