while if one could really do that it would be super powerful it is very complicated to actually measure those cells for writer reasons uh the two two biggest ones probably are uh i mean three big ones are there uh the cells are not very abundant when they are there there's very few of them and they're so they're very difficult to purify like you know to actually um purif you know a good purification they might still only be one percent or less of the cells in your purified sample because it's just so hard to purify it's finding a needle in the haystack and because it's intact cells you have to process the samples really quickly you have to process them basically the same day or within an hour or two of the patients having the blood sample drawn that makes it very difficult to build up biobanks of frozen cells a frozen samples that you could you know get a large cohort you could actually study because you have to press them immediately