my argument is you know that like when I talk about multimodality therapy for cancer it's you know about targeting those mechanisms that we can address inside the cancer cell it's about modulating the environment um metabolically U you know kind of actually even fixing to a degree this oxygen um you know pity of oxygen and in the pockets you know of that um as well as manipulating these other cell populations like immune cells um and turns out even like fiberblast for example like get recruited into certain cancers most notably pancreatic cancer