Methylation patterns on circulating tumor DNA can indicate the tissue of origin for a cancer.

“on that on the circul tumor DNA um as it's called you can actually do more than just sequence you know for mutations to find that it's circulating tumor DNA as opposed to normal DNA you can also look at what are called methylation patterns which is has to do with this kind of like folding and unfolding of the blueprint um these these molecular modif applications that that that exist in certain cell types um and basically if you find you know mutated sequence of DNA and it's got the methylation pattern of a colon epithelial cell guess what cancer you probably have right”