The evidence is convergent. Multiple independent sources reach the same conclusion, the underlying mechanism is well-characterized, and even the field's most cautious voices treat it as worth doing.
so cancer we we you know our cells become cancerous but they're clearly hijacked because they have these mutations and as a result of these mutations they make protein prots that allow cancers to behave differently and Cancers behave differently from non-cancer in two very critical ways the first way is that they do not respond to cell cycle signaling
Every Sunday: the week’s new conflicts and verdict changes — and nothing else.
Native comments, Twitter mentions, and Reddit threads about this claim — surfaced together so the conversation isn't fragmented across platforms.
Bookmarking — the dossier-vs-overview split is the right call. Most of the time I want overview; sometimes I want receipts.
Would love a "what would change this verdict" RSS feed. Sign me up if it exists.
one of the two things that defines a cancer cell and differentiates it from a normal cell so if you have somebody with colon cancer what is it about the colon cancer cells that is different from the regular colon cells one of them is this ability to leave the colon and go someplace else so colon cancer cells could now grow in the liver whereas regular colon cells if you put them in the liver wouldn't grow the second thing is basically the inability to respond to cell cycle signaling a regular cell from the colon will respond to signals that tell it to stop growing that's how it knows to stop so if you have an injury to the colon it will respond appropriately and grow to heal but then it will stop growing once it's told hey we're done we don't need you to grow anymore that's fine colon cancer cells won't do that those are the two hallmarks is not responding to growth signal stopping and being able to spread to your first question
as a result of these mutations they make proteins that allow cancers to behave differently and Cancers behave differently from non-cancer in two very critical ways the first way is that they do not respond to cellcycle signaling so if you cut your skin it heals but how does it know to heal just right and not to keep growing and growing and growing and growing and growing well it knows that because there are cycle signals that tell it time to grow time to stop... the second property of cancer is the capacity to leave the site of origin go someplace else and take up residence so that's metastasis that's the metastases component
Whole-body MRI screening in healthy adults produces more incidentaloma harm than cancer-mortality benefit.
Starting colonoscopy screening at 45 (vs 50) prevents enough early-onset cancers to justify the population cost.
Multi-cancer liquid-biopsy tests like Galleri detect early cancers at a stage that meaningfully improves survival.