you can see that um in breast cancer by the way we we always think about this in two forms we think about um herun new positive and negative estrogen receptor positive and negative and triple negative and um if anybody needs a refresher on that we have a a great podcast we did on breast cancer that explains why these are three basically very different diseases but you can see the difference in survival between all of these cancers at an early stage where it ranges from 92 to 100% stage 1 2 survival to stage four where you have metastatic disease it's 13 to 40%