Some cancers, like those associated with Lynch syndrome or hereditary polyposis, are derived from inherited germline mutations.

“so there are a handful of cancers that are uh derived from inherited mutations so Lynch syndrome is an example of that hereditary polyposis is an example of that where you have a gene that gets passed through the germ line and that Gene codes for a protein like all genes do and it's either you have too much of a gene or too little of a gene so it's either a gene that promotes cancer or and you have too much of that or it's a gene that prevents cancer and you have too little of it or a dysfunctional version of it right so braa is an example of that braa is hereditary braa codes for a protein and the the women and men but mostly the women that we think about who have a braa mutation that all in some cases almost guarantees breast cancer it's because of a defective copy so it's like they don't get the protein that they need to protect them from breast cancer”