in solid organ tumors there have been only two real breakthroughs in the last 50 years one has been the therapy for a certain type of IC cancer um and it's really just a chemotherapy cocktail that has been found to work really well and the other has been in this really rare kind of gastric cancer called The Gist stromal tumor which happens to result from one mutation in a kise pathway and there's one drug that can now Target that and it works it's kind of amazing cures that cancer cures that