Andrew Huberman· PhD
And if you look at the mechanism-- I mean, we know that LDL can penetrate the endothelium, so there's the mechanism is present.
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The evidence is convergent. Multiple independent sources reach the same conclusion, the underlying mechanism is well-characterized, and even the field's most cautious voices treat it as worth doing.
And if you look at the mechanism-- I mean, we know that LDL can penetrate the endothelium, so there's the mechanism is present.
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LDO I everything I could find both from your work and other work that I was looking at was the LDL probably moves through the endothelium into the intima in a normal process that's probably a normal process of LDL moving in it has to deliver things we know that there is there is endocytosis there is Tran cytosis which is an active process that things move through there but then they probably moved back out
an LDL molecule carrying its load of cholesterol maybe a little bit of triglyceride to boot um makes its way from the Lumen of the artery through the endothelial barrier between a couple of cells into a potential space called the subendothelial space